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Density Dependence of Expiratory Flow and Bronchodilator Response in Asthma

Atropine is a potent bronchodilator and has been used in children as well as adults with asthma and chronic bronchitis. Some of these studies have shown it to be useful especially in the presence of chronic bronchitis. Other workers have found it to be inferior to adrenergic agents. Most of these studies refer only to the acute bronchodilator effects of atropine, and its role in the long term treatment of asthma remains unclear. The uncertainty

Observations about Management of Asthma and COPD in Clinics

Incorporation of spirometry testing into these family medicine practices led to spirometry testing with acceptable levels of technical quality and concordant interpretation and was followed by management changes for almost half of the patients. Poor technical quality and low rates of concordant interpretations were limited primarily to two practices (G and J in Fig 2). Our results support previous work demonstrating moderate-to-high levels of technical adequacy and ability to accuracy interpret spirometry in primary care.

Outcomes about Management of Asthma and COPD in Clinics

The 12 practice investigators were all family physicians working in communities with populations <100,000. The 382 patients were mainly women (63%) and adults (76%) with a mean age of 46.1 years (SD, 19.9 years; range, 7 to 89 years). Overall, 248 patients (65%) had a previous diagnosis of asthma only, 100 patients (26%) had COPD only, and 32 patients (8%) had both asthma and COPD. Of the 382 patients, 2 patients withdrew before testing and

Spirometry Can Be Done in Family Physicians Offices and Alters Clinical Decisions in Management of Asthma and COPD

Primary care physicians diagnose and care for a significant portion of the millions of Americans with asthma and COPD. Yet, debate continues regarding the appropriateness, value, and barriers related to in-office spirometry in primary care practices for management of obstructive lung diseases. Studies show that technically adequate spirometry is possible, that screening spirometry of all primary care patients who smoke can identify COPD and modify some COPD treatment and that spirometry in children can be

Deliberation of Sympathoadrenal Reactivity in Exercise-induced Asthma

EIA is usually defined as a postexercise decrease in FEVi of 15 percent or a decrease in Sgaw of 35 percent compared with basal preexercise values. In the present study, all asthmatic patients had postexercise bronchoconstriction, but the severity of this reaction varied. When using a less sensitive parameter, such as FEVi, to evaluate bronchial tone, the postexercise measurements of the NEIA patients did not differ from those of the C group. With the more

Outlet about Sympathoadrenal Reactivity in Exercise-induced Asthma

At the time of the two exercise tests the relative humidity was 22 to 45 percent and the ambient temperature 22 to 24.5°C, as determined in 24 of the 48 experiments. Pretrial Examination Basal preexercise values for FEVi and VC were similar in the three groups, and all were within 75 percent of the predicted values. All patients with a history of EIA had decreases in FEVi of more than 15 percent following the pretrial

Sympathoadrenal Reactivity in Exercise-induced Asthma

It is well known that 3-adrenoceptor blockade may cause bronchoconstriction and that -adrenoceptor stimulation induces bronchodilation in patients with bronchial asthma. There is also evidence (or the existence of a-adrenoceptors in human airways, the stimulation of which may induce contraction of human bronchial smooth muscle. Conversely, a-adrenoceptor blockade may counteract or reduce bronchoconstriction provoked by allergen, exercise, or histamine. Hence, adrenergic mechanisms seem to be important for the regulation of bronchial tone in patients with bronchial asthma. This raises two

Deliberation of The Effect of Sch 1000 and Disodium Cromoglycate on Exercise-Induced Asthma

In this study, disodium cromoglycate and Sch 1000 were found to be effective in the prevention of exercise-induced asthma in the majority of patients. While most studies agree that disodium cromoglycate is partially effective in the prevention of exercise-induced asthma, the reports on the effectiveness of administration of atropine are conflicting. The finding of this study that inhalation of Sch 1000 prevents exercise-induced asthma in the majority of patients is in agreement with the results

Outcome of The Effect of Sch 1000 and Disodium Cromoglycate on Exercise-Induced Asthma

The baseline value for FEVi and the maximum percentage of change in FEVi after drug administration and after exercise are shown in Table 2. The FEVi measured before each study was very similar in each of the subjects. There was no change in FEVi after inhalation of placebo (mean changes, —0.2 percent). After inhalation of 20 mg of disodium cromoglycate, one patient (patient 6) developed acute bronchoconstriction , and the FEVi dropped by 55 percent; spontaneous recovery

The Effect of Sch 1000 and Disodium Cromoglycate on Exercise-Induced Asthma

Disodium cromoglycate has been shown in several studies to be partially effective in the prevention of exercise-induced asthma; however, the reports on the effectiveness of atropine are conflicting. While Sly et al showed that premedication with atropine failed to prevent exercise-included asthma in the majority of his patients, Simonsson and co-workers found that there was protection in six out of nine patients. Sch 1000 is a derivative of atropine (methyl bromide of N-isopropyl nortropine) and