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Cardio-selective Beta-adrenergic Therapy Report

Beta adrenergic therapy with propranolol is the therapy of choice in the treatment of hypertrophic obstructive cardiomyopathy. However, it is contraindicated in the presence of severe asthma. Recendy a cardio-selective β-1 adrenergic antagonist, pindolol, or 4-(2-hydroxy-3-isopropylaminopropoxy) indole has been developed with a potency equal to or greater than that of propranolol. Specific β-2 adrenergic agonists also are available for use in patients with asthma. Their effects on the cardiovascular system are minimal. We recently encountered

PY108-068, a New Calcium Antagonist, with Nifedipine in Exercise-Induced Asthma Deliberations

Part 1: Research about PY108-068, a New Calcium Antagonist, with Nifedipine in Exercise-Induced Asthma Part 2: PY108-068, a New Calcium Antagonist, with Nifedipine in Exercise-Induced Asthma Outcomes Bronchodilation and prevention of exercise-induced asthma are separate and useful goals of therapy for asthma. We studied a class of drugs that may have potential for meeting either or both of these goals. We found some resting bronchodilation associated with both 150 mg of PY 108-068 and nifedipine, although only the latter was significant. Some studies on calcium antagonists in asthma have not shown resting bronchodilation; however, measurements were only made

PY108-068, a New Calcium Antagonist, with Nifedipine in Exercise-Induced Asthma Outcomes

Article shows research outcomes based on data which is given in this article . Twelve of 16 subjects completed the study. Four subjects dropped out after the first day (two due to exacerbations of asthma thought unrelated to the study, one due to lack of cooperation, and one due to an unrelated illness). Resting bronchodilation, expressed as mean percentage of change in FEW from baseline, is shown in Figure 1. The peak bronchodilator effect of nifedipine occurred at

Research about PY108-068, a New Calcium Antagonist, with Nifedipine in Exercise-Induced Asthma

Many of the pathophysiologic events underlying asthma, including contraction of bronchial smooth muscle and degranulation of mast cells, are calcium-dependent. Because of this, studies have been done to determine the effect of calcium antagonists on pulmonary function in asthmatic subjects. These studies have measured the effect of these drugs on flow rates at rest and after various challenges including antigen histamine, hyperventilation, and exercise. Exercise has frequently been used because it is safe, natural, and

Absence of Relationships Between Tuberculin Responses and Development of Adult Asthma Observations

This study demonstrates that the magnitude of tuberculin response was similar among asthma-rhinitis and healthy, atopic and nonatopic Chinese adults in the Guangdong area. There was no association between tuberculin response, presence of BCG scars, and asthma and rhinitis as well as atopy. These results were consistent in both the univariate and multivariate analyses. We employed allergen SPT, serum-total, and serum-specific IgE levels as markers to indicate atopic status of our study subjects. These markers

Absence of Relationships Between Tuberculin Responses and Development of Adult Asthma Outcomes

The characteristics of the study and healthy control groups are presented in Table 1. By strictly adhering to the protocol of the study, the distribution of age and gender of subjects in both groups was similar. A significant higher proportion of asthma-rhinitis subjects had previous (45.8% vs 4.1%) and present (50.5% vs 2.7%) eczema as compared with healthy subjects. There were no differences between the two groups with regards to the percentage of subjects with

Absence of Relationships Between Tuberculin Responses and Development of Adult Asthma

The prevalence of allergic rhinitis and asthma has increased in many countries in recent decades. The reason for this increase is not clear but has been largely attributed to environmental factors such as exposure to aerial pollutants and early life events, including the degree of exposure to infectious agents that might affect IgE production. Extensive evidence suggests that the decrease of bacterial and viral infection because of the improvement of living standard and reinforcement of

Sputum Induction and Bronchoscopy for Assessment of Ozone-Induced Airway Inflammation in Asthma Observations

In this study, we used a model of irritant-induced nonspecific inflammation to compare these two methods of sampling RTLF. Inhaled O3 at high ambient concentrations can induce the recruitment of neutrophils into the airway lumen. This has been demonstrated by increases in both the concentration of polymorphonuclear neutrophils and the %PMNs in RTLF samples obtained by bronchoscopy as well as by SI. In our study, O3 exposure increased the %PMNs in BAL fluid and the

Sputum Induction and Bronchoscopy for Assessment of Ozone-Induced Airway Inflammation in Asthma Outcomes

Spirometry The mean (± SD) values of the spirometry indexes are shown in Table 2. The preexposure FEVj values for all subjects were similar in all arms of the study. Across FA exposures, there was a slight increase in FEV1. Across O3 exposures, there was a significant decrease in FEV1. The post-FA exposure FEV1 values for all subjects were similar in the SI and bronchoscopy arms of the study, as they were after O3. FVC

Sputum Induction and Bronchoscopy for Assessment of Ozone-Induced Airway Inflammation in Asthma Research

Study Design The study had a randomized crossover design. Subjects were exposed either to O3 or FA for 4 h followed by either bronchoscopy or SI 18 h later. Subjects then underwent the alternate exposure (O3 or FA) followed by the same method of airway lining fluid sampling. In the crossover part of the study, subjects repeated the same exposure protocol with the alternate method of airway Lining fluid sampling. Subjects Subjects were initially recruited