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Conscious Perception of Bronchospasm as a Protective Phenomenon in Asthma

It has been commonly accepted but poorly documented that in the presence of chronic asthma, patients may become adapted to the presence of their pulmonary dysfunction. They may, for instance, remain asymptomatic but taper their activities to a lower level; their degree of pulmonary dysfunction might possibly be grossly underestimated and their therapy less than optimal. In keeping with this apparent blunting of perceptive ability with longstanding dysfunction, one might expect the perception of further

Discussion about Corticosteroid in Asthma for Exercise-Induced Bronchoconstriction and Sputum Eosinophils Results

Read details in previous publications: Introduction: “ Corticosteroid in Asthma for Exercise-Induced Bronchoconstriction and Sputum Eosinophils “ Results: “ Corticosteroid in Asthma for Exercise-Induced Bronchoconstriction and Sputum Eosinophils Results “ In steroid-naive asthmatic subjects with EIB, we demonstrated that 40% had elevated (> 5%) baseline sputum eosinophil percentage counts. These subjects had a greater fall in FEV1 following a standardized exercise challenge. Sputum eosinophil percentage was significantly correlated to and was an independent predictor of EIB severity. Treatment with low and high doses of ciclesonide resulted in significant reduction in �V1 fall postexercise at

Corticosteroid in Asthma for Exercise-Induced Bronchoconstriction and Sputum Eosinophils Results

Introduction: Read more in previous publication “ Corticosteroid in Asthma for Exercise-Induced Bronchoconstriction and Sputum Eosinophils “. Twenty-six subjects (16 male subject) were enrolled into the study. The ratio of enrolled to screened subjects was 1:3 (Fig 1). One subject was excluded from all analyses due to inadequate sputum sample production, one subject did not crossover due to insufficient �V1 fall after washout, and another subject missed one visit due to a musculoskeletal injury. All data were included up to the time of study withdrawal.

Corticosteroid in Asthma for Exercise-Induced Bronchoconstriction and Sputum Eosinophils

Fosinophils may be important in the pathophysiology of exercise-induced bronchoconstriction (EIB) and the response to therapy in patients with chronic asthma ( read more ). In vitro studies have demonstrated that eosinophils generate and release cysteinyl leu-kotrienes when subjected to a hyperosmolar stimulus, which is an important condition that provokes EIB. Cysteinyl leukotrienes are potent bronchocon-strictor mediators that are implicated in EIB. Furthermore, the presence and severity of EIB is significantly correlated to eosinophil levels measured in

Results and Disscusion of Wheezing in Acute Asthma Quantitation

To learn this research materials and methods follow this link . Twenty patients, with a mean age of 43 years, were studied. Eighteen of the 20 were female. All 20 had audible wheezing before treatment; 12 of them still had some wheeze after treatment. All patients showed improvement in their FEV1 the mean value for the group rose from 1.15±0.39 L (mean±SD) before treatment to 1.49 ±0.43 L after treatment. Peak expiratory flow rates improved from 150

Quantitation of Wheezing in Acute Asthma Methods

During an acute attack of asthma, auscultation of the patients lungs is likely to be repeated many times. The severity of the attack, the improvement or deterioration, and the response to treatment are judged by several criteria, such as the patients symptoms, physical findings, pulmonary function tests , and blood gas analysis; but repeated auscultation plays an important part in assessment. Auscultation is simple, is readily available, requires only a stethoscope, and entails no risk or inconvenience to

FEV1 Performance Among Patients With Acute Asthma Observations

Grapple with previous articles relating to this topic: FEV1 Performance Among Patients With Acute Asthma Research FEV1 Performance Among Patients With Acute Asthma Outcomes In contrast to most outpatient settings, the patients studied were acutely ill and severely obstructed and not expecting to perform spirometry during their ED visit. This study shows that with a strong emphasis on several quality measures, spirometry for the purpose of obtaining an FEV1 can be performed in acutely ill ED asthmatics. Most patients (almost three quarters) were able to perform study-specific acceptable and reproducible tests

FEV1 Performance Among Patients With Acute Asthma Outcomes

A total of 641 patients from 20 sites were enrolled in the clinical trial. Performance data from 620 of 641 patients (97%) with 3,782 time points and 13,615 spirometry maneuvers were available for analysis. The missing data included all performance data from 1 site (four patients), leaving 19 sites in the analysis. Spirometry was performed by 107 different investigators, two thirds of whom had no previous experience performing spirometry. The average patient age was 33

FEV1 Performance Among Patients With Acute Asthma Research

Current practice guidelines for the treatment of an acute asthma exacerbation, such as in the emergency department (ED) setting, recommend that objective measures of pulmonary function such as peak expiratory flow (PEF) and FEV1 be used. Mechanical peak flow meters are most commonly used in the ED setting since they are inexpensive and easy to use. However, FEV1 as a measure of asthma severity has advantages compared to PEF. These include greater accuracy, less effort dependence, better repeatability,

Cardio-selective Beta-adrenergic Therapy Considerations

The classic studies of Ahlquist divided adrenergic agents into two main types, a and β, based on their relative physiologic effects. Those with primarily β-adrenergic activity have been further subdivided by Lands and associates into two major subgroups: β-1 associated with lipolysis and cardiac inotropy, and β-2 with bronchodilation and vasodilation. It is recognized that β-adrenergic agonists and antagonists, although relatively selective in their effects, may overlap with regard to β-1 responses depending on the