Considerations of Anticholinergic Drug, Ipratropium Bromide (Sch 1000), as an Aerosol in Chronic Bronchitis and Asthma
Atropine has been administered parenterally and by inhalation to prevent and curtail asthmatic attacks. Gold and associates showed that procedures decreasing vagal stimulation, including intravenous or aerosol treatment with atropine, could prevent increases in airway resistance caused by several different antigens in dogs. Pretreatment of asthmatic patients with atropine can block their shortterm response to methacholine and certain antigens. Intravenous administration of atropine to dogs prevented bronchospasm induced by intravenous or aerosol administration of serotonin