Atropine

Considerations of Anticholinergic Drug, Ipratropium Bromide (Sch 1000), as an Aerosol in Chronic Bronchitis and Asthma

Atropine has been administered parenterally and by inhalation to prevent and curtail asthmatic attacks. Gold and associates showed that procedures decreasing vagal stimulation, including intravenous or aerosol treatment with atropine, could prevent increases in airway resistance caused by several different antigens in dogs. Pretreatment of asthmatic patients with atropine can block their shortterm response to methacholine and certain antigens. Intravenous administration of atropine to dogs prevented bronchospasm induced by intravenous or aerosol administration of serotonin

Tagged: asthma , bronchitis , Inhalation , Ipratropium bromide , placebo , prednisone
bronchial-asthma

Data of Anticholinergic Drug, Ipratropium Bromide (Sch 1000), as an Aerosol in Chronic Bronchitis and Asthma

In the group with bronchial asthma, all doses of ipratropium and isoproterenol produced significant (P < 0.05) improvements in the FEVi, compared with the placebo, within five minutes of administration. The duration of significant improvement in FEVi was less than 15 minutes after the lO^g dose of ipratropium bromide; it was 30 minutes after the 20/xg dose of ipratropium bromide and after 75/xg of isoproterenol, one hour for 150/ig of isoproterenol, and up to four hours after the

Tagged: asthma , bronchitis , Inhalation , Ipratropium bromide , placebo , prednisone
Ipratropium-bromide

Bronchodilator Action of the Anticholinergic Drug, Ipratropium Bromide (Sch 1000), as an Aerosol in Chronic Bronchitis and Asthma

Ipratropium bromide (N-isopropyl-notropine-tropic acid ester methylbromide), also known as Sch 1000, is an atropine-like agent which has been developed as an aerosol bronchodilator drug. This compound is believed to produce bronchodilata-tion by inhibiting increases in levels of cyclic guano-sine monophosphate mediated by cholinergic receptors, as contrasted with the action of adrenergic receptor stimulants in raising levels of cyclic adenosine monophosphate . Previous investigations have shown effective bronchodilation by ipratropium in asthmatic patients. This study was undertaken to establish

Tagged: asthma , bronchitis , Inhalation , Ipratropium bromide , placebo , prednisone