Systolic blood pressure

Results of Terbutaline in the Treatment of Acute Asthma in Childhood

Of the 48 patients, 24 received terbutaline, and 24 received epinephrine. The average age of the group receiving terbutaline was nine years (range, 4 to 16 years) and of those receiving epinephrine was seven years (range, 2 to 13 years). Appreciable clinical improvement was noted in 19 of 24 patients in both groups and was of comparable magnitude. All of the patients were grouped into four subgroups, those receiving one injection of terbutaline or of

Tagged: asthma , bronchodilator , clinical improvement , terbutaline
Acute asthmatic attack

Terbutaline in the Treatment of Acute Asthma in Childhood

AIthough there have been a few studies on the effect of terbutaline in children, none has compared the effect of terbutaline with the effect of epinephrine during the acute asthmatic attack . In a parallel study, we have demonstrated the efficacy of terbutaline in the treatment of status asthmaticus in children. Because those patients by definition were unresponsive to treatment with epinephrine, ethical and practical considerations precluded us from comparing the effects of terbutaline with epinephrine in that

Tagged: asthma , bronchodilator , clinical improvement , terbutaline
Bronchial asthma

Beta Adrenergic Agonists: Subsensitivity

Subsensitivity or tolerance is a diminished responsiveness which develops in many physiologic systems when receptors are repeatedly exposed to increased levels of their agonist either natural or administered. With chronic administration, subsensitivity develops to the beta adrenergic agonists and results in a reduced bronchodilator response. Ibis occurs over a period of one to two weeks and requires a similar period of time to reverse after the beta adrenergic drug has been discontinued. In vitro studies

Tagged: adrenergic subsensitivity , bronchial asthma , bronchodilation , Cardiac stimulation , epinephrine , Inhalation , leukocytes , observation
Inhalation

Beta Adrenergic Agonists: The Role of Beta Adrenergic Bronchodilators in the Treatment of Asthma

Inhaled beta adrenergic bronchodilators are the treatment of choice for prompt relief of acute episodes of wheezing and dyspnea no matter what has been the stimulus. Although exercise-induced bronchoconstriction can be prevented by therapy with cromolyn, theophylline or oral beta adrenergic agonists, it is most conveniently and effectively prevented with the least number of side effects by inhalation of a long-acting adrenergic bronchodilator shortly before beginning exercise. The relative role of beta adrenergic agonists and theophylline

Tagged: adrenergic subsensitivity , bronchial asthma , bronchodilation , Cardiac stimulation , epinephrine , Inhalation , leukocytes , observation
Adrenergic subsensitivity

Beta Adrenergic Agonists: Specific Beta Adrenergic Bronchodilators

Epinephrine is still the drug of choice for treatment of acute anaphylaxis where a combination of alpha and beta adrenergic properties are desirable. It is still employed in the treatment of severe asthma , and several recent studies have confirmed the efficacy of injections of 0.25 mg (0.01 mg/kg in small children) repeated at 15 to 20 minute intervals in the treatment of patients with acute bronchoconstriction. The principal alternative to epinephrine in the United States is terbutaline. Even

Tagged: adrenergic subsensitivity , bronchial asthma , bronchodilation , Cardiac stimulation , epinephrine , Inhalation , leukocytes , observation
Bronchial asthma

Beta Adrenergic Agonists

Beta adrenergic agonists and theophylline are the principal bronchodilators employed in the treatment of bronchial asthma. During the last decade, the clinical usefulness of theophylline has been enhanced by the availability of serum theophylline determinations and sustained release formulations. Beta adrenergic bronchodilators were initially somewhat eclipsed in the United States by these improvements in theophylline therapy . Now, however, with the introduction of selective and long lasting adrenergic agents, appreciation of their role in the treatment of

Tagged: adrenergic subsensitivity , bronchial asthma , bronchodilation , Cardiac stimulation , epinephrine , Inhalation , leukocytes , observation

Targeting Improvements in Asthma Morbidity in Chicago: Research Initiatives

In addition to basic research on asthma biology and genetics ongoing in many Chicago centers, Chicago has been an important center for clinical studies in asthma in the past 10 years. The School-based Pediatric Asthma Research in Chicago investigators analyzed the social, behavioral, environmental, and biological factors influencing racial and ethnic disparities in childhood asthma in Chicago. School-based ASMA program helps adolescents improve asthma management, quality of life . A short questionnaire, completed by parents, was used to screen > 11,000 children in 14 Chicago public

Tagged: childhood asthma , high-efficiency particulate air , School-based Pediatric Asthma Research , symptoms
Asthma therapy

Targeting Improvements in Asthma Morbidity in Chicago: Surveillance Initiatives

Many organizations, consortia, and collaboratives collected and distributed information on asthma prevalence and severity, attitudes, and behaviors regarding asthma therapy in various clinical settings, and knowledge and attitudes about asthma in Chicago communities. In data workshops sponsored by the CAC annually since 1997, epidemiologists, community leaders, and health-care providers have presented focused analyses of many of the issues concerning asthma in Chicago. University of Chicago and Chicago Department of Public Health epidemiologists have developed detailed

Tagged: asthma therapy , Chicago Asthma Surveillance Initiative , Illinois Emergency Department Asthma Collaborative
Asthma

Targeting Improvements in Asthma Morbidity in Chicago: Education Initiatives

Numerous organizations, community groups, researchers, and medical providers have assumed an active role in addressing the asthma education needs of various sectors in the city heavily impacted by asthma. School-Based Efforts Asthma 101, a program of proven benefit that teaches 8- to 11-year-old students how to manage asthma, and Open Airways for Schools (OAS), an asthma awareness program for faculty and school staff, have been utilized by several organizations to increase local, neighborhood capacity for

Tagged: asthma management , asthma problem , medical providers , Open Airways for Schools
Asthma in children

Targeting Improvements in Asthma Morbidity in Chicago: Disparity Initiatives

Chicago is a city with a high concentration of people from lower socioeconomic groups; these groups typically show higher asthma prevalence and morbidity. Over the past 10 years, there have been a number of community-based strategies that focused on reducing asthma disparities. A few of these projects are highlighted. The Mobile C.A.R.E. Foundation operates two medical vans to provide free and comprehensive medical care, health education, and medications to children with asthma in underserved communities. Its goal is

Tagged: asthma morbidity , Controlling Asthma , environmental risk factors , medications