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Quantitation of Wheezing in Acute Asthma Methods

During an acute attack of asthma, auscultation of the patients lungs is likely to be repeated many times. The severity of the attack, the improvement or deterioration, and the response to treatment are judged by several criteria, such as the patients symptoms, physical findings, pulmonary function tests , and blood gas analysis; but repeated auscultation plays an important part in assessment. Auscultation is simple, is readily available, requires only a stethoscope, and entails no risk or inconvenience to

Bronchial Asthma Treatment with Amiodarone Research and Outcomes

Read the article previously published on this topic – “ Bronchial Asthma Treatment with Amiodarone Report “. Amiodarone (courtesy of Dr. A. Curran, Reckitt and Colman Pharmaceutical Division, Sydney) was dissolved in methanol (1 mg/ml) and diluted in assay buffer immediately prior to use. The range of concentrations employed (10 to 1,000 ng/ml) was of the order reported in human plasma after therapeutic doses. Human pulmonary cells (VA-13 line, American Type Culture, Bethesda, Md) were grown in RPMI 1640 medium supplemented

Bronchial Asthma Treatment with Amiodarone Report

Amiodarone is an antiarrhythmic agent which is useful in the treatment of a wide range of tachyarrhythmias , including the prevention of paroxysmal supraventricular arrhythmias. Among other electrophysiologic properties, amiodarone is an “antagonist to catecholamines and sympathomimetic agents without causing beta blockade” (product information literature, Reckitt and Colman, Sydney). Studies in isolated tissues from animals have shown that amiodarone is a noncompetitive adrenergic antagonist. Despite many years of clinical experience with this drug in Europe and South

FEV1 Performance Among Patients With Acute Asthma Observations

Grapple with previous articles relating to this topic: FEV1 Performance Among Patients With Acute Asthma Research FEV1 Performance Among Patients With Acute Asthma Outcomes In contrast to most outpatient settings, the patients studied were acutely ill and severely obstructed and not expecting to perform spirometry during their ED visit. This study shows that with a strong emphasis on several quality measures, spirometry for the purpose of obtaining an FEV1 can be performed in acutely ill ED asthmatics. Most patients (almost three quarters) were able to perform study-specific acceptable and reproducible tests

FEV1 Performance Among Patients With Acute Asthma Outcomes

A total of 641 patients from 20 sites were enrolled in the clinical trial. Performance data from 620 of 641 patients (97%) with 3,782 time points and 13,615 spirometry maneuvers were available for analysis. The missing data included all performance data from 1 site (four patients), leaving 19 sites in the analysis. Spirometry was performed by 107 different investigators, two thirds of whom had no previous experience performing spirometry. The average patient age was 33

FEV1 Performance Among Patients With Acute Asthma Research

Current practice guidelines for the treatment of an acute asthma exacerbation, such as in the emergency department (ED) setting, recommend that objective measures of pulmonary function such as peak expiratory flow (PEF) and FEV1 be used. Mechanical peak flow meters are most commonly used in the ED setting since they are inexpensive and easy to use. However, FEV1 as a measure of asthma severity has advantages compared to PEF. These include greater accuracy, less effort dependence, better repeatability,

Increase in Bronchial Responsiveness to Methacholine and Late Asthmatic Response Deliberations

Read previous publications regarding to this research: Increase in Bronchial Responsiveness to Methacholine and Late Asthmatic Response Increase in Bronchial Responsiveness to Methacholine and Late Asthmatic Response Outcomes The present study demonstrates that in asthmatic subjects, bronchial sensitivity to methacholine can increase after the inhalation of ultrasonically nebulized distilled water. The increase in bronchial responsiveness can persist for more than two hours after the recovery from the bronchospasm induced by the distilled water. This confirms previous results obtained by Black and co-workers; however, those authors studied the change in responsiveness to methacholine only 40 to 60

Increase in Bronchial Responsiveness to Methacholine and Late Asthmatic Response Outcomes

Team of Asthma Inhalers Online presents this topic overview in article “ Increase in Bronchial Responsiveness to Methacholine and Late Asthmatic Response “. Preliminary Study The mean values for PC20UNDW (± SD in log scale) observed during three successive challenges with ultrasonically nebulized distilled water were 2.24 ± 0.80, 2.15±0.69, and 2.04±0.62 ml/min. These values were not significantly different by analysis of variance (p>0.1). No subject showed any progressive shifting to the right of the output-response curve indicative of refractoriness (Fig 1). Spontaneous Variability of FEV1 and PC20M On the

Increase in Bronchial Responsiveness to Methacholine and Late Asthmatic Response

Bronchoconstriction elicited by the inhalation of ultrasonically nebulized distilled water’ is presumed to be at least partly provoked by a nonimmuno-logic release of mediators from mast cells in the airways. Recent evidence has suggested this hypothesis. In fact, circulating concentrations of the mast cell-associated mediators, histamine and neutrophilic chemotactic factor, increase in asthmatic subjects after inhalation of ultrasonically nebulized distilled water. This accompanies the development of distilled water-induced asthma in a way analogous to the

Cardio-selective Beta-adrenergic Therapy Considerations

The classic studies of Ahlquist divided adrenergic agents into two main types, a and β, based on their relative physiologic effects. Those with primarily β-adrenergic activity have been further subdivided by Lands and associates into two major subgroups: β-1 associated with lipolysis and cardiac inotropy, and β-2 with bronchodilation and vasodilation. It is recognized that β-adrenergic agonists and antagonists, although relatively selective in their effects, may overlap with regard to β-1 responses depending on the