Entocort Inhaler

Basic information: Entocort inhaler is used for controlling asthma symptoms in patients with this disease.

Entocort Inhaler
  • Brand Name: Entocort
  • Generic Name: Entocort EC
  • Preparation:: Inhalers: 100mcg
Product Price Per pill Order
1 inhaler x 100 mcg $64 $64 Buy Now
3 inhalers x 100 mcg $145.92 $48.64 Buy Now
6 inhalers x 100 mcg $268.8 $44.8 Buy Now

Entocort is available on Asthma Inhalers Online, buy inhalers and get rid of asthma attacks.

Entocort Inhaler Instruction for Use

Pharmaceutical Form, Composition and Packing

Enteric capsules, hard gelatin, size №1, opaque, white; contents of capsules – round pellets, white.
1 caps. contains 3 mg of budesonide. Additive agents: sugar nibs – 300 mg; lactose monohydrate – 12 mg; povidone K25 – 0.9 mg; copolymer from methacrylic acid and methyl methacrylate (1: 1) (Eudragit L) – 18.3 mg; copolymer of methacrylic acid and methyl methacrylate (1: 2) ( Eudragit S) – 18.3 mg; methylmethacrylate copolymer, trimethylamine monia methyl methacrylate chloride and ethyl acrylate (Type B) [2: 0.1: 1] – 3 mg; methyl methacrylate, trimethylamine monia methyl methacrylate chloride and ethyl acrylate (Type A) [2: 0.2: 1] – 2.1 mg; triethyl citrate – 4.2 mg; talc – 44.7 mg.

The composition of capsule shell (body): gelatin – 38,076 mg; water – 6,612 mg; titanium dioxide – 0.912 mg.

The composition of capsule shell (lid): gelatin – 25,384 mg; water – 4,408 mg, titanium dioxide – 0.608 mg.

Pharmacology

Glucocorticosteroids (GCS) for local use have anti-inflammatory, anti-allergic and immunosuppressive effect. Entocort inhaler increases lipocortin production, inhibitor of phospholipase A2, inhibits release of arachidonic acid, inhibits synthesis of products of arachidonic acid metabolism – cyclic endoperoxides and Pg.

It prevents neutrophils boundary accumulation, reduces inflammatory exudation and production of cytokines, inhibits macrophages migration, reduces infiltration and granulation processes severity, chemotactic substances formation (which explains efficacy in “late” reactions, allergies), inhibits mast cell inflammatory mediators release ( “immediate” allergic reaction).

Entocort inhalers increase number of “active” beta-adrenergic receptors, restore patient’s response to bronchodilators by reducing frequency of their use, reduce bronchial mucosa edema, mucus production, mucus formation and reduce airway hyperresponsiveness. This medication increases mucociliary transport. It has fungicidal action. It is well tolerated in long-term care and does not have ISS activity, almost has no resorptive action.

Therapeutic effect of budesonide develops after an average of 5-7 days. Budesonide inhalation is able to prevent asthma attack, but does not reduce acute bronchospasm.Entocort Inhaler

Indications for Use

Clinico-pharmacological group: glucocorticosteroids for oral use. Entocort Budesonide Inhaler is used for purpose in case of seasonal allergic rhinitis, bronchial asthma, vasomotor, rhinitis asthma. To prevent nasal polyps growth, in case of polypectomy. Reviews about Entokort are positive, which are a measure of efficiency of use, thanks to patients with experience in taking drug.

Mechanism of Action

The drug belongs to the group of corticosteroids which are used for topical, inhalative application. It is able to provide anti-allergic, anti-inflammatory effects. Expressed clinical effect manifests itself in a period of 5-7 days from therapy initiation date.

Dosage and Administration

It is applied as inhalation, using a special inhaler (turbuhaler). Each capsule of inhaler contains 200 doses of budesonide, one serving of powder from capsule dispenser detachable inhaler contains 200 micrograms of budesonide. Entokort is inhaled 200-800 mg / day for 2-4 breaths.

Budesonide powder is preferably used for inhalation. If previous treatment of bronchial asthma was carried out only by beta2-agonists and inhaled corticosteroids – 200-400 g (1-2 inhalation) 2 times a day; if applied systemic corticosteroids – 400-800 g (2-4 inhalation) 2 times a day.

The maximum dose of budesonide in patients receiving only beta2-adrenoceptor agonist, – 800 mg / day; for patients previously treated with inhaled or systemic corticosteroids, – 1600 mg / day.

Children over 6 years: 1 inhalation (200 micrograms / day), maximal – 2 2 inhalations twice daily (400 mg / day).

Suspension for inhalation. Adults – 2.1 mg for children 3 months-12 years – 0.25-1 mg, 2-4 ml prediluted NaCl solution, if necessary, two times a day. After receiving effect you should reduce dose to the lowest effective required to maintain a stable state.

In cases where the patient is taking corticosteroids orally, translation to budesonide therapy is possible in disease’s stable phase (for 10-14 days and combine inhalation GCS inside, then gradually reduce dose by mouth until complete abolition).

Side Effects

The most widespread side effects when applying Entokort Inhaler are:

  • hoarseness;
  • throat irritation;
  • oral cavity candidiasis.

Contraindications

Main contraindications include:

  • tuberculosis;
  • fungal infections;
  • sensitivity to drug’s ingredients;
  • skin viral diseases;
  • respiratory system disorders.

Interaction

Preliminary inhalation of beta-agonists dilates bronchi, improves flow of medication to airways and enhances therapeutic budesonide effect.
Receiving 200 mg ketoconazole 1 time per day increases oral budesonide in a dose of 3 mg in an average in 6 times in plasma concentration. When assigning ketoconazole 12 hours after receiving last budesonide concentration in plasma is increased 3 times. Information about such interactions with inhaled budesonide dosage forms is not studied, however, expect noticeable increase in plasma concentration of drug.

Phenobarbital, phenytoin, rifampin, and other inducers of microsomal oxidation reduce effectiveness of corticosteroids systemic budesonide effect (induction of enzymes of microsomal oxidation).

Metandienone, estrogens increase budesonide effect.

Special Instructions

Prior to drug’s use, it is necessary to shake canister and turn it upside down, and then to place nozzle in your mouth, and during deep inspiration you should press on the valve. After completing inhalation procedure, you need to rinse your mouth.

Precautionary Methods

Storing of this medication should be in package to prevent moisture ingress, and light. It is important to respect temperature at a rate not greater than 30 degrees. In addition, it is important to keep precautions and store medication in a place where it will not be accessible for children.

Additional Information

To avoid side effects symptoms and achieve maximum drug’s effectiveness in bronchial asthma treatment, it is necessary to adhere strictly to dosage and course of treatment prescribed by attending specialist. To buy Entokort via Asthma Inhalers Online, you can use menu of self-filling of order form or contact us using our e-mail: support@onlineasthmainhalers.com. An operator will answer all your questions. Our company can guarantee high quality of proposed drug which price is lower than in ordinary drug stores, since all deliveries executed only from manufacturers already proven worldwide.